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BLAST 2.2.13 now available

The new release includes a new engine for blastall, changes to statistical parameters, and bug fixes. BLAST 2.2.13 is now available on the BLAST download page.   Major changesNew engine now available...

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BLAST 2.2.14 now available

BLAST release 2.2.14 offers a universal binary for Mac OS X, and improved performance on some platforms. BLAST 2.2.14 is now available on the BLAST download page. Major Changes blastall now uses the...

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Special Announcement: Beta Test of New BLAST Interface

NCBI is holding a beta test for a new BLAST interface design. Special Announcement: Beta Test of New BLAST Interface. NCBI is holding a beta test for a new BLAST interface design. We invite you to try...

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New BLAST Redesign in Production

After beta testing the new BLAST pages will become the default BLAST portal as of 04/16/2007. April 2, 2007: New BLAST design to be released on April 16, 2007...

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New BLAST URL available

The NCBI has activated a new URL for BLAST searches at the NCBI: http://blast.ncbi.nlm.nih.gov. Searches sent to this URL can take advantage of a larger number of machines for searches and the system...

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BLAST report improvements

To use the new report select the link "Please, try our new design!: at the top right corner of the report.   In this modified report the information at the top of the BLAST report is better organized...

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New tree view available

A detailed list of improvement are:   - Two new evolutionary distance models for protein sequences developed by N. Grishin that allow construction of guide trees between sequences with more than 75%...

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BLAST interface described in NAR web server issue

Free full text for this article about the NCBI BLAST web interface is available at http://nar.oxfordjournals.org/cgi/content/full/36/suppl_2/W5

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Find specific primers with Primer-BLAST

Primer-BLAST was developed to help users make primers specific to a PCR template. Primer-BLAST combines primer design (using Primer3) and a specificity check via a BLAST search. The specificity check...

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Align Sequences with BLAST

The NCBI BLAST web pages (blastn, blastp, blastx, tblastn, tblastx ) have a new option to align a query against a set of target sequences, rather than a BLAST database.This option allows you to align...

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BLAST 2.2.19 now available

New BLAST binaries are available on the NCBI FTP site....   List of changes: The BLASTDB environment variable now supports multiple database search paths.When possible, a smaller protein lookup table...

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Align two sequences form.

The Align two sequences link on the BLAST home page now uses the standard BLAST submission form.   The Align two sequences link from the BLAST home page at blast.ncbi.nlm.nih.gov now uses the standard...

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BLAST 2.2.20 now available

New BLAST binaries are available on the NCBI FTP site....  The list of changes are:1.) Ungapped blastn searches allow arbitrary reward/penalty scores.2.) Spaces are allowed in database pathnames on...

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SRA transcript BLAST

454 transcript sequences are now searchable through BLAST.  The search sets are grouped by organism and include all public 454 transcript sequences in the NCBI SRA database.  Go to...

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Multiple Alignments with COBALT

COBALT incorporates pairwise constraints into a progressive multiple alignment.    The pairwise constraints are derived from the conserved domain database, the protein motif database, and sequence...

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BLAST 2.2.21 now available

This release includes new BLAST+ command-line applications. The BLAST+ applications have a number of advantages over the older applications that include working more robustly with long sequences and a...

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Limit by organism improved

There is a new feature to include or exclude multiple organisms from a search.   The BLAST web pages now allow you to exclude organisms from your search as well as limit you search to multiple...

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BLAST 2.2.22 now available

This release includes new BLAST+ command-line applications. The BLAST+ applications have a number of advantages over the older applications and users are encouraged to migrate to the new applications....

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Exclude Models and environmental samples

New checkboxes in the "Choose Search Set" section of the BLAST search pages exclude Model sequences (XM/XP) and environmental samples.    The environmental sample sequences are identified with the...

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BLAST+ article in BMC Bioinformatics

A new article, BLAST+: architecture and applications, describes improvements for long sequences as well as other new BLAST features. The BMC Bioinformatics article is available from...

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