DELTA-BLAST performs more sensitive protein-protein searches.
Since 1997, the BLAST web site has offered searches with a “Position Specific Scoring Matrix” (PSSM) through the PSI-BLAST program. This normally required the user to launch a few searches. Domain Enhanced Lookup Time Accelerated BLAST (DELTA-BLAST) is a new addition to the web site that performs a PSSM search. It runs a fast RPSBLAST search in order to construct the PSSM and then searches the PSSM against a BLAST database. Tests using the SCOP based benchmark set demonstrate that DELTA-BLAST yields retrieval accuracy greater than BLASTP and similar to a few PSI-BLAST iterations. The DELTA-BLAST results can also be used to initiate a PSI-BLAST search.
You may start a DELTA-BLAST search from the protein-protein page.
An article in Biology Direct describes the DELTA-BLAST algorithm and benchmark results.
Since 1997, the BLAST web site has offered searches with a “Position Specific Scoring Matrix” (PSSM) through the PSI-BLAST program. This normally required the user to launch a few searches. Domain Enhanced Lookup Time Accelerated BLAST (DELTA-BLAST) is a new addition to the web site that performs a PSSM search. It runs a fast RPSBLAST search in order to construct the PSSM and then searches the PSSM against a BLAST database. Tests using the SCOP based benchmark set demonstrate that DELTA-BLAST yields retrieval accuracy greater than BLASTP and similar to a few PSI-BLAST iterations. The DELTA-BLAST results can also be used to initiate a PSI-BLAST search.
You may start a DELTA-BLAST search from the protein-protein page.
An article in Biology Direct describes the DELTA-BLAST algorithm and benchmark results.